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Taking Antibiotics: What You Need to Know – Use, Risk + Tips

March 25, 2025

Tufts Medicine infectious disease experts share the facts about the safe and responsible use of antibiotics.

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Antibiotics are strong medicines that help fight infections caused by bacteria. They don’t work for everything, and you need to take them the right way. Here’s what you need to know about when you might get an antibiotic, why you might need a different one and why, in many cases, antibiotics are not the answer. 

What are antibiotics for?

Antibiotics fight infections caused by bacteria. We only give them when needed, and we don’t give them when they won’t work. Antibiotics don’t work for colds, or most coughs or sore throats, which are caused by viruses. Antibiotics can cause unpleasant side effects like an upset stomach (nausea), diarrhea or rash. They kill the healthy bacteria that live and perform important functions in your body, so it’s important to take them only when they are absolutely necessary. Whenever someone takes antibiotics, bacteria living in their body can become resistant to those antibiotics, and those bacteria can spread to others. 

Taking antibiotics only when needed helps protect your health and makes sure these life-saving medicines will work for you and others in the future. We’ll answer any questions you have about antibiotics. 

Why don’t antibiotics work for a cold?

Antibiotics only work for bacterial infections, like strep throat, skin infections or some urinary tract infections. They don’t work for viral infections, like the common cold, most stomach bugs and even some more serious illnesses flu or COVID-19. Taking antibiotics when you don’t need them can make bacteria harder to treat later. This is called antibiotic resistance, and it can make infections harder to fight. 

  • Takeaway: Antibiotics don’t work for viruses like the common cold.

Why might you need a different antibiotic?

Not all antibiotics work the same way. Your doctor will pick the right one based on:

  • Any allergies to antibiotics
  • The type of infection you have
  • Your medical history

If one antibiotic doesn’t work, your doctor might switch you to another.

  • Takeaway: Different infections need different antibiotics.

Why might you not receive an antibiotic today for certain conditions you may have received one for in the past? 

Antibiotic resistance is rising worldwide, making infections harder to treat and leading to more serious illness and even death. In the past, doctors often prescribed antibiotics “just in case” for certain symptoms and conditions. Now, we know this can have serious consequences. Some conditions that used to be treated with antibiotics but usually shouldn’t be today include sinusitis, bronchitis, positive urine cultures without symptoms and agitation in older adults.

Things to know about antibiotics

  • Never share antibiotics: Someone else may need a different type or dose.
  • Never take antibiotics that were not prescribed for you: Antibiotics are sold over-the-counter in some countries. Take only antibiotics prescribed specifically for your current condition. 
  • Take them exactly as prescribed: Don’t skip doses or save leftovers for later. Ask your doctor or pharmacist if you have any questions about how to take your prescription.
  • Some antibiotics can affect birth control pills: Ask your doctor if this applies to you. 
  • Some antibiotics are not recommended during pregnancy: Notify your doctor before taking an antibiotic if you are or might be pregnant. 
  • Watch for side effects: Upset stomach, diarrhea or rashes are common. Call your doctor if symptoms are severe.
  • Available in liquid or pill form: Let your doctor know if you have a preference. If you are prescribed the liquid form, ask your pharmacist if the medication can be crushed or replaced with another formulation. 

When to call your doctor when taking antibiotics

It’s important to stay on top of your health while taking antibiotics. If something doesn’t feel right or your symptoms change, don’t hesitate to reach out to your doctor. Call your doctor if:

  • You don’t feel better after a few days
  • You have a bad reaction
  • Your symptoms get worse

If you experience a severe rash, have trouble breathing or feel lightheaded or dizzy, call 911 or go to the closest emergency department immediately. These could be signs of a serious allergic reaction or other emergency.

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Myth vs. fact: What you need to know about antibiotics

  • Myth: If you have a fever, you need an antibiotic. 
  • Fact: Fevers can be caused by viruses, bacteria, other germs or even causes not related to infection. Only bacteria are treatable with antibiotics.
     
  • Myth: Antibiotics work on all infections. 
  • Fact: They only work on bacterial infections, and specific antibiotics work for specific infections. 
     
  • Myth: If antibiotics don’t work, you just need a stronger dose. 
  • Fact: Some bacteria are resistant, meaning a different antibiotic might be needed. 
     
  • Myth: All antibiotics are the same. 
  • Fact: Different antibiotics work for different types of bacterial infections. 
     
  • Myth: Taking leftover antibiotics from a previous illness will help with a new infection. 
  • Fact: You should never take leftover antibiotics. They may not work for the new infection and can contribute to resistance. 
     
  • Myth: Taking more antibiotics will make them more effective.
  • Fact: Taking more antibiotics than prescribed can harm your body and lead to resistance. 
     
  • Myth: Bacteria are bad and should be eliminated with antibiotics. 
  • Fact: Our bodies are inhabited by billions of “good bacteria” that serve vital functions like helping us digest our food and protecting us from bad bacteria. Antibiotics kill both bad and good bacteria. Killing the good bacteria can have a negative impact on our health, which is why antibiotics should only be used when absolutely necessary.  

Bacterial vs. viral infections: What's the difference?

  • Bacterial Infections: Caused by bacteria, which are tiny living organisms that can invade your body and cause illness. Bacteria are responsible for infections like strep throat, urinary tract infections (UTIs) and pneumonia. These infections can usually be treated with antibiotics, which kill or stop the growth of bacteria.
  • Viral Infections: Caused by viruses, which are even smaller than bacteria and need to invade healthy cells in your body to multiply. Viruses cause illnesses like the flu, the common cold and COVID-19. Antibiotics do not work for viral infections. The body usually fights viral infections on its own, though antiviral medications may be prescribed for certain viruses.
     
Infection typeExamplesWill antibiotics work?
BacterialStrep throat, UTIs, some sinus infectionsYes
ViralColds, flu, COVID-19, most sore throats, most coughsNo

Other antibiotic resources

Antibiotics save lives when used the right way. Knowing when and how to use them helps keep you and everyone around you healthier. Here are some resources that can help you learn more about antibiotics:

Not feeling your best? 

Use our online symptom checker to find out what to do next, call your primary care doctor or visit urgent care for fast, expert care.

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FAQs

What is antibiotic resistance?

Antibiotic resistance happens when bacteria change over time and become less affected by antibiotics. When bacteria become resistant, it means they can continue to grow and spread, even when you're taking medicine to fight them. This makes infections harder to treat and can lead to longer illnesses, more doctor visits, or the need for stronger medications. It’s important to only take antibiotics when prescribed and to follow your doctor’s instructions closely to help prevent antibiotic resistance. 

Can antibiotics cause yeast or other infections?

Yes. Antibiotics can kill good bacteria in your body, which may lead to yeast infections or stomach problems like diarrhea. To help prevent these issues, consider: 

  • Eating foods with probiotics, like yogurt or kefir, which some studies suggest might help replace the good bacteria. 
  • Stay in close contact with your doctor since some infections caused by antibiotics require treatment. 

If you notice itching, unusual discharge or stomach problems, talk to your doctor. 

Can I share my antibiotic with someone else?

No, you should never share your prescription with someone else. Antibiotics and other medications are prescribed specifically for your health needs, and what works for you might not be safe or effective for someone else. Sharing antibiotics can also contribute to antibiotic resistance, making future infections harder to treat. If someone else needs medication, they should see a doctor for their own prescription.  

What should I do if I miss a dose?

Take it as soon as you remember unless it’s almost time for your next dose. Never take two doses at once. Contact your pharmacist if you have questions. 
 

Can I drink alcohol while taking antibiotics?

Some antibiotics don’t mix well with alcohol. This will be written on the bottle.  

Do antibiotics have side effects?

Like any medication, antibiotics can cause mild side effects like headache, nausea or diarrhea. You could be allergic to certain antibiotics and should stop taking them and call your doctor right away if you experience itching, rash, swelling of the lips or tongue or shortness of breath. Some antibiotics:

  • Are less safe in pregnancy
  • Can cause an injury to your esophagus
  • Impact the effectiveness of your birth control
  • Increase your risk of sunburn

Ask your doctor or pharmacist what to watch out for, read the prescription bottle and materials carefully, and do not hesitate to call your doctor if you are experiencing any new symptoms.  
 

Committed to your health

At Tufts Medicine, we care about your health. We only give antibiotics when necessary to make sure they stay effective and protect health for future generations.

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