This is a single site, prospective, cross-sectional, controlled clinical study on a total of 66 subjects. The subjects are divided into two groups: HS non-responders (33 subjects) and HS responders (33 subjects). After completion of questionnaires, the subjects will undergo DED testing and functional nerve testing. Subjects who qualify will be dispensed 4 weeks of preservative free artificial tears and instructed to instill one drop into each eye twice daily. Subjects will return for a follow up visit 4 weeks later (± 4 days), during which subjects will complete the questionnaires again and the DED tests and functional nerve tests will be repeated.
PreDICT
Predicting the Success of Dry Eye Disease Treatment Using Hyperosmolarity Drops
Dry eyes
All genders
18+
Recruiting now
Overview
Principal Investigator: Stephanie Cox, DO
Contact Us
Bethany Saul, Michael Dixon
Study details
Inclusion Criteria
- Diagnosis of Dry Eye Disease Anesthetized
- Schirmer test of <10 mm over 5 minutes
- Tear break-up time (TBUT) of ≤5 seconds
Exclusion Criteria
- Unable to complete questionnaires in English
- History of ocular surgery, corneal infection, or corneal injury within the last 3 months
- Changes in topical or systemic medications in the last 3 months or anticipated changes in medication during the course of treatment
Study Requirements
After completion of questionnaires, the subjects will undergo DED testing and functional nerve testing. Subjects who qualify will be dispensed 4 weeks of preservative free artificial tears and instructed to instill one drop into each eye twice daily. Subjects will return for a follow up visit 4 weeks later (± 4 days), during which subjects will complete the questionnaires again and the DED tests and functional nerve tests will be repeated.