This is a study of the prevalence of APOL1 alleles in adults who are of recent African ancestry or geographic origin. The study will enroll up to a total of approximately 2500 subjects into 2 groups. Group 1 includes subjects with FSGS, and Group 2 includes subjects with other forms of proteinuric nondiabetic CKD. No study drug will be administered.
VX19-NEN-801
A Study of the Prevalence of Apolipoprotein L1 (APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin
Chronic kidney disease, Glomerular disease, Kidney diseases, Proteinuria
All genders
12-65
Recruiting now
Overview
Principal Investigator: Daniel Weiner, MD, MS
Contact Us
Katie Ferguson
Study details
Inclusion Criteria
- African ancestry or geographic origin, which may include but is not limited to
the following: Black, Caribbean, African American, SubSaharan African, or LatinX (defined
as a person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish
culture or origin). - Group 1: FSGS OR proteinuric nondiabetic Chronic Kidney Disease
Exclusion Criteria
- Subject has end-stage kidney disease, defined as being on chronic dialysis.
- Subject has had a kidney transplant.
- Subject has diabetes mellitus.
Study Requirements
This study includes a single visit. A blood sample will be collected for APOL1 genotyping. A saliva sample will be collected for exploratory use in APOL1 genotyping assay development.