wtATTR-CIAP Burden Study

Dissecting the neuropathic burden in wtATTR: its role in staging and burden of disease, and in differentiating from chronic idiopathic axonal polyneuropathy

Transthyretin cardiac amyloidosis

All genders

18+

Recruiting now

Principal Investigator: Dr. Oscar Soto and Dr. Maria Bartkus

This is an observational study to assess the the burden of neuropathic involvement in wild-type transthyretin amyloidosis

Neuro Research

Inclusion Criteria

At least 18 years of age
Ability to provide informed consent
Adult diagnosed with of ATTR by immunohistochemistry and TTR genetic testing without pathogenic variant. Tafamidis (+) and tafamidis (-) or Chronic idiopathic axonal polyneuropathy (CIAP)

Exclusion Criteria

Evidence of polyneuropahty of any cause or disorder commonly associated with polyneuropathy such as: diabetes mellitus, renal insufficiency, hypothyroidism, vitamin B12 deficiency, and paraproteinemia

Study Requirements

Day 1 Screening

Review of your medical record
Obtain informed consent
Phone interview with Dr. Bartkus Day 1 Baseline assessments- in Neurology Dept. at TMC
Questionnaire Administration • Nerve conduction studies
Quantitative sensory testing • Heart rate deep breathing
Quantitative Sweat Measurement System (Q-Sweat)
Cutaneous and Mixed Nerve Silent Period (CSP, MSP) Week 52 (1-year) Follow-up
Longitudinal assessment phone call (optional)