Radiology Research

• Clinical Trial: EF-32 (TRIDENT): A pivotal randomized, open-label study of OPTUNE concomitant with radiation therapy and temozolomide for the treatment of newly diagnosed glioblastoma
• Prospective study of POCUS ultrasound in an at-risk neonatal population
• Pelvic ultrasound for non-obstetric pelvic pain: Do not miss anatomy for residents on call
• A call for screening MRI as a tool for osteoarthritis clinical trials
• Emerging quantitative imaging techniques in sports medicine
• Strategic application of imaging in DMOAD clinical trials: focus on eligibility, drug delivery, and semiquantitative assessment of structural progression
• Role of imaging for eligibility and safety of a-NGF clinical trials
• An overuse-related injuries of the knee
• Application of artificial intelligence for musculoskeletal imaging (such as fracture detection and spinal scoliosis measurements)
• State of the heart: a pictorial review of classic and novel cardiac devices
• Patient and clinical factors associated with timeliness of follow-up of incidentally detected lung nodules
• PQI-creation of database for active learning files for rotating medical students in radiology
• Lung nodule clinic – smoking cessation program/program pilot; joint creation with pharmacology, surgery, pulmonology, and radiology
• A phase II trial of GM-CSF plus maintenance pembrolizumab +/pemetrexed after completion of first line chemo-immunotherapy in advanced non-small cell lung cancer patients with PDL-1 of 1%-49%
• The utility of XV device in assessing ventilatory limitations in individuals with post-acute sequelae of SARS-CoV-2 infection
• Assessing the feasibility of coronary artery scoring as part of an ongoing phase III study of chemoimmunoradiation stage IIIB lung cancer
• Researching COVID to Enhance Recovery (RECOVER) – a participating member of the Boston COVID Research Consortium (BRBC)
• Imaging of dementia using 18F FDG PET: Unique and overlapping features
• Renal biopsy after implementation of onsite glomerulus counts: Quality and safety analysis
• Large bore portal vein thrombectomy: An Inari FlowTriever case series
• Risk of infection for tunneled lines placed in ICU patients – a single center experience
• Pulmonary artery pseudoaneurysm secondary to Swan-Ganz catheter balloon inflation

Recently completed or on-going research projects being conducted by members of the Department:

• Do-Dai, D: Co-P.I. - A Multi-Center, Double-Blind, Randomized Study Comparing the Combined use of Interferon Beta-1a and Glatiramer Acetate to Either Agent Alone in Patients with Relapsing Remitting Multiple Sclerosis (CombiRx-Phase III). PI: Jeffrey Chavin, MD. This trial is not yet open, but has IRB approval.
  
  Do-Dai, D: Co-P.I. - A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent, Glioblastoma Subjects to Compare the Efficacy of AZD2171 [RECENTIN(tm)], Monotherapy and the Combination of AZD2171 with Lomustine to the Efficacy of Lomustine Alone. PI: Jay-Jiguang Zhu, MD, PhD. This trial has been postponed until summer 2008.
• Halin, N: Co-P.I. – Halt-PKD Study
• Ji, H: Hepatic Fat Quantification Using Three-point Dixon Sequence and MRS
  3T pelvic MRI in patients with infertility
  Body diffusion/perfusion imaging
  Functional liver imaging using liver specific MR contrast
  Quantitative MR imaging for assessing the tumor metabolism
• Ji, H: Bayer investigator sponsored study (accepted): $30,000, Role: PI
  Title: Gd-EOB-DTPA-enhanced MRI of the liver in patient with primary sclerosing cholangitis: Correlation between hepatocystic-phase enhancement with Mayo Risk Score.
• Ji, H: Tufts Clinical and Translational Sciences Institute 2009 pilot (submitted), Role: PI
  Title: Functional imaging of tumor using quantitative MR imaging biomarkers
• Ji, H: Tufts Medical Center Research Fund (not accepted), Role: PI       
  Title: Tissue characterization of abdominal tumors using quantitative MR imaging biomarkers.
• Ji, H: Co-Mentor on funded NIH grant (K23) – Oct.2009:  “HIV: Metabolic Complications”, PI: Rakhi Kohli, MD, Assistant Professor, Division of Geographic Medicine and Infectious Disease, Department of Medicine, Tufts University School of Medicine
• Ji, H: NIH Research Fund (submitted), Role: co-PI
  Title: Nutritional status of HIV-positive Hispanic drug users.
• Ji, H: NIH Research Fund (submitted), Role: co-PI
  Title: Prevalence of peripheral fat atrophy, central fat deposition and insulin resistance in HIV-infected persons
• Ji, H: Co-PI on NIH grant (R21) – Jan. 2010:  “Hepatic fat and insulin resistance in HIV/HCV co-infected Hispanics vs. Whites,” PI: Janet Forrester, PhD, Associate Professor, Department of Public Health & Community Medicine, Tufts University School of Medicine
• Ji, H: Co-PI on NIH grant (R01) – Feb. 2010:  “Insulin Resistance in Hepatitis C-Infected Hispanics vs. Whites”, PI: Janet Forrester, PhD, Associate Professor, Department of Public Health & Community Medicine, Tufts University School of Medicine
• 2005-10: NIH/NHLBI1 R01 HL081352-01. (P.I. Polak) 35% effort; Progression of sub-clinical Atherosclerosis in the Framingham Offspring Cohort. Total Direct $1,868,632; Total IDC $458,825
• Polak, JF:  RO-1:  Progression of atherosclerosis in MESA (year 5/5, currently on no cost extension).
• Polak, JF: RO-1:  Progression of atherosclerosis in the Framingham Offspring cohort (currently entering year 4/5)
• Nikpoor, N: GFR Measurement with Radioactive tracer (I125 iotalomate) is in progress.
• Do-Dai, D: Co-Investigator with Neuro-Oncology (PI: Dr. Zhu) of clinical trials, Tufts Medical Center
• Do-Dai, D: AstraZenica-AZD2171: A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Patients to Compare the Efficacy of Cediranib  [RECENTIN™, AZD2171] Monotherapy and the Combination of Cediranib with Lomustine to the Efficacy of Lomustine Alone.
• Do-Dai, D: NovoCure-EF14: A Prospective, Multi-center Trial of NovoTTF-110A Together with Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed Glioblastoma Multiforme
• Do-Dai, D: Myriad-MPC-6827: A Phase II Study of Azixa™ (MPC-6827) for the Treatment of Patients with Glioblastoma Multiforme or Anaplastic Gliomas in First Relapse
• Daly, K: Quality Measures in Interventional Radiology, Development of an online radiology educational and clinical management tool utilizing open source software.
• Ward, RJ: Osteoarthritis/Vitamin D study in conjunction with Rheumatology
• Ward, RJ: Osteoarthritis/DXA in conjunction with Rheumatology
• Ward, RJ: Histologic analysis of OA with MRI correlation
• Ward, RJ: Evaluation of ulnar variance as a function of positioning with respect to MRI

Resident research projects for residents of the past two years which led or will lead to presentations at local or national meetings.

• Aftab, M., Erbay S, Han R, Polak J, Bhadelia R. Correlation between intracranial arterial calcium and differential patterns of cerebral parenchymal atrophy.  Poster presentation at American Society of Neuroradiology Conference (ASNR) 2006.
• Baccei S, Han R, Sarno R.  Patient and Radiologist Bellyache: Acute Complications of Bariatric Surgery.  To be presented at RSNA, Chicago, IL 2007 [educational poster presentation].
• Baccei S, Han R, Doherty F. Ultrasound Imaging of Post-Transplant Liver Complications With Multimodality Correlation.  ARRS, Orlando, FL 2007 [educational poster presentation].
• Brooks, MK. Multimodality imaging of Paget’s Disease. Planning to submit for 2008 RSNA
• Han R, Bagga S.  Pediatric Nuclear Medicine: a Brief Overview. ARRS, New Orleans, LA 2005 [educational poster presentation]
• Han R, Bagga S.  Radionuclide Therapy with I-131: Review of Imaging Patterns, Treatment Protocols, Pitfalls, and Pearls. ARRS, New Orleans, LA 2005 [educational poster presentation]
• Han R, Nikpoor N.  Different Scintigraphic Patterns of Superscan. ARRS, Vancouver, Canada 2006 [educational poster presentation]
• Han R, Baccei S, Erbay S, Bhadelia R, Krakov W, Polak J.  Correlation between Intracranial Arterial Calcium, Cerebral Ischemic Parenchymal Changes, and Cardiovascular Risk Factors with Multifactorial Analysis.  American Society of Neuroradiology, San Diego, CA 2006 [scientific poster presentation]
• Han R, Nikpoor N.  Correlation Between Different Types of Superscan on Tc-99 MDP Bone Scan and Underlying Disease.  RSNA, Chicago, IL 2006 [scientific poster presentation]
• Han R, Sarno R.  Perfusion Gone Bad: Review of Avascular Necrosis. RSNA, Chicago, IL 2006 [educational poster presentation]
• Han R, Sarno R. Review of Wrist Pain: An Interactive Quiz.  ARRS, Orlando, FL 2007 [educational poster presentation]
• Han R, Samenfeld-Specht M, Sarno R.  Weight Reduction Surgery: Imaging Appearance of Complications.  To be presented at RSNA, Chicago, IL 2007 [educational poster presentation].
• S. Erbay, R. Han, R. Sarno.  Trauma of the Upper Extremity.  To be presented at RSNA, Chicago, IL 2007 [educational poster presentation]
• Jamarayan M, Mayo-Smith W, Han R, Dupuy D, Movson J. Multi-Institutional Computer Database for Tracking CT- and US-guided Interventions.  RSNA, Chicago, IL, 2001[oral scientific presentation]
• Tedesco K, Bhadelia R. Association between Fractional Anisotropy in the Corpus Callosum and Quantitative Measures of Gait and Balance in Elderly Individuals. January 2006 Presented as a scientific paper at the 45th Annual Meeting of the American Society of Neuroradiology (June 2007)
• Tedesco K, Bhadelia R. Increased Cochlear Signal on FLAIR Images in Patients with Acoustic Neuroma: A Manifestation of High Protein Levels in Perilymph. November 2006. Presented as a scientific paper at the 45th Annual Meeting of the American Society of Neuroradiology (June 2007)
• Tedesco K, Bagga S. Correlative Imaging in the Diagnosis of Hepatic Hemangiomas: Patterns, Pearls, and Pitfalls. 2005. Journal of Nuclear Medicine 2005: 46, Supplement 2: 253-254. Poster Presented at the Society of Nuclear Medicine, Toronto, Ontario, Canada. June 2005