Transcranial magnetic stimulation (TMS) has proven to be a useful tool to characterize corticospinal drive in awake behaving humans. For example, increased corticospinal drive associated with voluntary contraction results in facilitation of the TMS-elicited motor evoked potential (MEP) relative to the MEP at rest. Given the pathophysiological processes in ALS that disrupt corticospinal drive, quantifying failure of facilitation can be used to detect UMN dysfunction, potentially providing a biomarker at earlier stages of the disease.
Articles
December 18, 2024
Chloe E. Bird, PhD, Director of the Center for Health Equity Research at Tufts Medical Center and Sarah Murray Jordan, Professor of Medicine at Tufts University School of Medicine, on a new report examining gaps in women’s health research and funding.