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The MCRI Mouse Physiology Core Laboratory is dedicated to the application of whole-animal models to pursue questions related to the pathophysiology of cardiovascular disease. The MCRI has established a series of cardiovascular models in rodents that are in active use in both the MCRI and in laboratories around the U.S. and the world. Models developed at the MCRI include a mouse model of carotid injury; chronic myocardial infarction, transverse aortic constriction and others. Phenotyping methods developed at the MCRI Mouse Core include a closed chest electrophysiology catheter-based procedure and dual ventricular pressure volume loop recording among others. The Mouse Core also routinely performs standard disease models and phenotyping assays relevant to cardiac and vascular physiology, including models of ventricular pressure overload, left and right ventricular pressure-volume loop analysis, cardiac echocardiography, telemetry implantation for blood pressure and ECG monitoring and many others.

The mission of the MCRI Vascular Function Core Laboratory at Tufts Medical Center is to uncover novel vascular physiological mechanisms that contribute to cardiovascular disease onset and progression in a variety of healthy and disease states. Our approach is translational in that our techniques allow vascular function assessment from rodent models up to clinical human studies.

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Tufts Medicine is on a journey to re-imagine healthcare, and it starts by looking at ourselves. We are on a mission to build an inclusive culture where all people can thrive by advancing diversity, cultural competence and eliminating structural racism to achieve health equity.

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For decades, it’s been known that poor nutrition during pregnancy has negative impacts on maternal and child outcomes both in the short and long term. Unfortunately, due to socioeconomic and food access issues, likely secondary to structural racism in populations of color, nutrition in pregnancy is also an issue of health equity.

EpicCare Link is an online tool for connecting physicians and their staff to Tufts Medicine resources and patient information in a secure manner.

The Department of Psychiatry at Tufts Medical Center offers a 24-hour per week practicum for doctoral students in Clinical and Counseling Psychology from September through May each year.

MCRI is comprised of 12 scientists dedicated to investigating the molecular mechanisms of common cardiovascular diseases and translating those discoveries into new clinical strategies for diagnosis and therapy to prevent and treat heart diseases including heart attack, high blood pressure and heart failure.

MCRI is composed of 3 centers: the Cardiac Biology Research Center, Vascular Biology Research Center and the Center for Translational Pharmacology and Genomics. These centers support the collaborative environment in the MCRI bringing together MCRI faculty and collaborators to advance each area of research.

The MCRI core labs include the MCRI Bio Bank Core Lab, the MCRI Cell Culture Core Lab, the MCRI Interventional Research Core Lab, the MCRI Small Animal Physiology Core Lab and the MCRI Vascular Function Core Lab. These labs provide equipment, infrastructure, and expertise to support MCRI faculty and trainees in their research.

The MCRI sponsors Multidisciplinary Research Groups that foster collaboration among clinical, translational and basic scientists including MCRI faculty and investigators across Tufts Medicine and Tufts University. These groups include the Cardio-Oncology Research Group, the Cardio-Renal Research Group, the Vasculo-Neuro Research Group, the Women’s Cardiovascular Health Research Group, and the Wound Healing Research Group.

Training the next generation of cardiovascular researchers is critical to the Molecular Cardiology Research Institute (MCRI) mission and a high priority in the Institute

Heart failure remains the leading cause of hospital admission in the United States. The Blanton laboratory investigates the basic molecular signaling mechanisms regulating the process of cardiac remodeling: the myocardial structural and functional abnormalities that ultimately cause the heart failure syndrome. Our overarching goal is to discover novel anti-remodeling signaling molecules in the heart which will enable us to design more effective and better-tolerated therapies for heart failure patients.

The Chin lab is interested in the molecular mechanisms that mediate the development of cardiomyopathies, with a particular focus on the genetic events that occur within the myocardium that result in myocardial dysfunction. Major areas of interest include the pathogenesis of hypertrophic cardiomyopathy (HCM), an inherited disorder that affects approximately 1 in 500, through transcriptomic, proteomic and metabolomic assessment, and the development of an enzyme replacement therapy for Barth Syndrome (BTHS), an inherited cardiomyopathy resulting from mitochondrial dysfunction.