We use these methods at Tufts Medicine and in research communities to generate evidence and improve care. We develop and demonstrate novel and impactful solutions to challenges across the translational research spectrum in collaboration with the other Institute for Clinical Research and Health Policy Studies (ICRHPS) and Clinical and Translational Science Institute (CTSI) centers, with Tufts University, and with multisite research networks. We promote interdisciplinary dialog on the application of advanced informatics and analytics for the improvement of health.